Molecular probes, chemosensors, and nanosensors for optical detection of biorelevant molecules and ions in aqueous media and biofluids
Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …
innovative assay protocols hold great potential for the development of robust, low-cost, and …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
Exploring the role of sphingolipid-related genes in clinical outcomes of breast cancer
S Pei, P Zhang, L Yang, Y Kang, H Chen… - Frontiers in …, 2023 - frontiersin.org
Background Despite tremendous advances in cancer research, breast cancer (BC) remains
a major health concern and is the most common cancer affecting women worldwide. Breast …
a major health concern and is the most common cancer affecting women worldwide. Breast …
Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia
Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage
disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) …
disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) …
A new update of MALDI-TOF mass spectrometry in lipid research
KM Engel, P Prabutzki, J Leopold, A Nimptsch… - Progress in lipid …, 2022 - Elsevier
Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is an
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …
Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …
Cholesterol–the devil you know; ceramide–the devil you don't
TS Tippetts, WL Holland, SA Summers - Trends in pharmacological …, 2021 - cell.com
Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …
Metabolomic signatures associated with pulmonary arterial hypertension outcomes
Background: Pulmonary arterial hypertension (PAH) is a complex disease characterized by
progressive right ventricular (RV) failure leading to significant morbidity and mortality …
progressive right ventricular (RV) failure leading to significant morbidity and mortality …
Lipids in the cell: organisation regulates function
Lipids are fundamental building blocks of all cells and play important roles in the
pathogenesis of different diseases, including inflammation, autoimmune disease, cancer …
pathogenesis of different diseases, including inflammation, autoimmune disease, cancer …
[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …
AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …
that a significant portion of the affected individuals developed long-term debilitating …