MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells
S Zanotti, S Vanhauwaert, C Van Neste, V Olexiouk… - Scientific Reports, 2021 - nature.com
MYCN is an oncogenic driver in neural crest-derived neuroblastoma and medulloblastoma.
To better understand the early effects of MYCN activation in a neural-crest lineage context …
To better understand the early effects of MYCN activation in a neural-crest lineage context …
Proteostasis collapse halts G1 progression and delimits replicative lifespan
Loss of proteostasis and cellular senescence are key hallmarks of cell aging, but whether
they are subject to direct cause-effect relationships is not known. We show that most yeast …
they are subject to direct cause-effect relationships is not known. We show that most yeast …