Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
DN Cooper, M Krawczak, C Polychronakos… - Human genetics, 2013 - Springer
Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
The continuing value of twin studies in the omics era
The classical twin study has been a powerful heuristic in biomedical, psychiatric and
behavioural research for decades. Twin registries worldwide have collected biological …
behavioural research for decades. Twin registries worldwide have collected biological …
Transgenerational epigenetic inheritance in mammals: how good is the evidence?
SD van Otterdijk, KB Michels - The FASEB Journal, 2016 - Wiley Online Library
Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic
marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are …
marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are …
Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships
Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …
associated with a broad range of disease traits, including cancer, asthma, metabolic …
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific …
Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an
estimation of the relative contribution of genetic and shared and nonshared environmental …
estimation of the relative contribution of genetic and shared and nonshared environmental …
Homosexuality as a consequence of epigenetically canalized sexual development
Male and female homosexuality have substantial prevalence in humans. Pedigree and twin
studies indicate that homosexuality has substantial heritability in both sexes, yet …
studies indicate that homosexuality has substantial heritability in both sexes, yet …
Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of …
Background The extent to which development-and age-associated epigenetic changes are
influenced by genetic, environmental and stochastic factors remains to be discovered. Twins …
influenced by genetic, environmental and stochastic factors remains to be discovered. Twins …
Translational perspective on epigenetics in cardiovascular disease
A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …
expression and providing a basis for the development and progression of cardiovascular …
You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring
K Vanhees, IGC Vonhögen, FJ van Schooten… - Cellular and molecular …, 2014 - Springer
The research field of fetal programming has developed tremendously over the years and
increasing knowledge suggests that both maternal and paternal unbalanced diet can have …
increasing knowledge suggests that both maternal and paternal unbalanced diet can have …
Evidence for a causal association of low birth weight and attention problems
MM Groen-Blokhuis, CM Middeldorp… - Journal of the American …, 2011 - Elsevier
OBJECTIVE: Low birth weight (LBW) is associated with attention problems (AP) and
attention-deficit/hyperactivity disorder (ADHD). The etiology of this association is unclear …
attention-deficit/hyperactivity disorder (ADHD). The etiology of this association is unclear …