Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Oxidative stress is a reflection of the imbalance between the production of reactive oxygen
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Encapsulation of injury with fibrosis is a highly evolved response of adult tissues. In liver, the
components of the process have been greatly clarified, leading to a coherent view of how …

Abstract Background/Aims: High‐fat dietary intake and low physical activity lead to insulin
resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis …

In the liver, the progressive accumulation of connective tissue, a complex and dynamic
process termed fibrosis, represents a very frequent event following a repeated or chronic …

Tissue fibrosis contributes to nearly half of all deaths in the developed world and is
characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models …