Neurobiology of addiction: a neurocircuitry analysis

GF Koob, ND Volkow - The Lancet Psychiatry, 2016 - thelancet.com
Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

The brain on drugs: from reward to addiction

ND Volkow, M Morales - Cell, 2015 - cell.com
Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2 production

H Chun, H Im, YJ Kang, Y Kim, JH Shin, W Won… - Nature …, 2020 - nature.com
Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …

Direct and indirect pathways of basal ganglia: a critical reappraisal

P Calabresi, B Picconi, A Tozzi, V Ghiglieri… - Nature …, 2014 - nature.com
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …

Interface engineering of highly efficient perovskite solar cells

H Zhou, Q Chen, G Li, S Luo, T Song, HS Duan… - Science, 2014 - science.org
Advancing perovskite solar cell technologies toward their theoretical power conversion
efficiency (PCE) requires delicate control over the carrier dynamics throughout the entire …

The ins and outs of the striatum: role in drug addiction

LM Yager, AF Garcia, AM Wunsch, SM Ferguson - Neuroscience, 2015 - Elsevier
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …

Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

D Charvin, R Medori, RA Hauser… - Nature Reviews Drug …, 2018 - nature.com
Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …

Concurrent activation of striatal direct and indirect pathways during action initiation

G Cui, SB Jun, X Jin, MD Pham, SS Vogel… - Nature, 2013 - nature.com
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected
by a number of debilitating neurological disorders,,,. The prevailing model of basal ganglia …

Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors

PE Rothwell, MV Fuccillo, S Maxeiner, SJ Hayton… - Cell, 2014 - cell.com
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …

The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding

C Varin, A Cornil, D Houtteman, P Bonnavion… - Nature …, 2023 - nature.com
The basal ganglia are known to control actions and modulate movements. Neuronal activity
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …