Neurobiology of addiction: a neurocircuitry analysis
GF Koob, ND Volkow - The Lancet Psychiatry, 2016 - thelancet.com
Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …
a combination of exaggerated incentive salience and habit formation, reward deficits and …
The brain on drugs: from reward to addiction
ND Volkow, M Morales - Cell, 2015 - cell.com
Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2− production
Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …
Direct and indirect pathways of basal ganglia: a critical reappraisal
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …
Interface engineering of highly efficient perovskite solar cells
Advancing perovskite solar cell technologies toward their theoretical power conversion
efficiency (PCE) requires delicate control over the carrier dynamics throughout the entire …
efficiency (PCE) requires delicate control over the carrier dynamics throughout the entire …
The ins and outs of the striatum: role in drug addiction
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …
intake, high motivation to obtain the drug, and a persistent craving for the drug …
Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …
addressing the loss of dopamine and dopaminergic function linked with degeneration of …
Concurrent activation of striatal direct and indirect pathways during action initiation
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected
by a number of debilitating neurological disorders,,,. The prevailing model of basal ganglia …
by a number of debilitating neurological disorders,,,. The prevailing model of basal ganglia …
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors
PE Rothwell, MV Fuccillo, S Maxeiner, SJ Hayton… - Cell, 2014 - cell.com
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …
corresponding mutations produce robust synaptic and behavioral changes. However …
The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding
C Varin, A Cornil, D Houtteman, P Bonnavion… - Nature …, 2023 - nature.com
The basal ganglia are known to control actions and modulate movements. Neuronal activity
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …