Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …

Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively
degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive …

In neurodegenerative diseases, microglia switch to an activated state, which results in
excessive secretion of pro-inflammatory factors. Our work aims to investigate how this …

Contact inhibition enables noncancerous cells to cease proliferation and growth when they
contact each other. This characteristic is lost when cells undergo malignant transformation …

Disruption of mitochondrial function and protein homeostasis plays a central role in aging.
However, how these processes interact and what governs their failure in aging remain …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Neurodegenerative diseases, characterized by a progressive loss of brain function, affect
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …

Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and
Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since …