Each year, millions of humans fall victim to animal envenomings, which may either be
deadly or cause permanent disability to the effected individuals. The Nobel Prize-winning …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

The snake is the symbol of medicine due to its association with Asclepius, the Greek God of
medicine, and so with good reasons. More than 725 species of venomous snakes have …

The blood plasma of numerous snake species naturally comprises endogenous
phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may …

Infectious diseases are among the leading global causes of death, increasing the search for
novel antibacterial agents. Among these, biologically active peptides are an excellent …

It is now more than a century since Albert Calmette from the Institut Pasteur changed the
world of envenomation by demonstrating that antibodies raised against animal venoms have …

Background: The prevalent class of snake venom serine proteases (SVSP) in Viperidae
venoms is the thrombin-like enzymes, which, similarly to human thrombin, convert fibrinogen …

Crotoxin, a phospholipase A 2 (PLA 2) complex and the major Crotalus venom component,
is responsible for the main symptoms described in crotalic snakebite envenomings and a …

CRISPs represent a family of cysteine-rich secretory proteins with molecular mass between
20 and 30 kDa and a highly conserved specific pattern of 16 cysteine residues. In this work …

It is of popular and scientific knowledge that toxins from snake venom (among them the
PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and …