A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and
secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the …

Inflammation participates importantly in host defenses against infectious agents and injury,
but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells …

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially
superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as …

Bonds between adhesion molecules are often mechanically stressed. A striking example is
the tensile force applied to selectin–ligand bonds, which mediate the tethering and rolling of …

Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …

Cell‐cell and cell‐substratum interactions are mediated through several different families of
receptors. In addition to targeting cell adhesion to specific extracellular matrix proteins and …

Abstract SEROTONIN (5-hydroxytryptamine, 5-HT) is a monoaminergic neurotransmitter that
is believed to modulate numerous sensory, motor and behavioural processes in the …

BACKGROUND: A growing number of recent investigations have established a critical role
for leukocytes in propagating tissue damage after ischemia and reperfusion in stroke …