[HTML][HTML] The effectiveness of metabolic bariatric surgery in preventing gynecologic cancer-from pathophysiology to clinical outcomes

N Machairiotis, AG Pantelis, A Potiris… - Journal of …, 2024 - ncbi.nlm.nih.gov
Obesity and cancer represent two pandemics of current civilization, the progression of which
has followed parallel trajectories. To time, thirteen types of malignancies have been …

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

LM Sipe, M Chaib, EB Korba, H Jo, MC Lovely… - Elife, 2022 - elifesciences.org
Bariatric surgery is a sustainable weight loss approach, including vertical sleeve
gastrectomy (VSG). Obesity exacerbates tumor growth, while diet-induced weight loss …

[HTML][HTML] Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer

KK Camp, MF Coleman, TL McFarlane, SS Doerstling… - JCI insight, 2023 - ncbi.nlm.nih.gov
Obesity promotes triple-negative breast cancer (TNBC), and effective interventions are
urgently needed to break the obesity-TNBC link. Epidemiologic studies indicate that bariatric …

The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications

M El-Tanani, SA Rabbani, AA Aljabali… - Nutrition and …, 2024 - Taylor & Francis
Obesity has emerged as an important global health challenge, significantly influencing the
incidence and progression of various cancers. This comprehensive review elucidates the …

High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice

M Ofosu‐Boateng, F Shaik, S Choi, FA Ekuban… - …, 2024 - Wiley Online Library
Although obesity and subsequent liver injury are increasingly prevalent in women, female
mouse models have generally shown resistance to high‐fat diet (HFD)‐induced obesity. We …

FXR agonism with bile acid mimetic reduces pre-clinical triple-negative breast cancer burden

SC Joseph, S Eugin Simon, MS Bohm, M Kim, ME Pye… - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer (BC) is the most common malignancy and the leading cause
of cancer mortality in women. It is possible that signals arising from the gut microbiome are …

The impact of microbially modified metabolites associated with obesity and bariatric surgery on anti-tumor immunity

Y Guo, L Qi, O Chen, S Chandra, D Zou - Frontiers in Immunology, 2023 - frontiersin.org
The human intestinal microbiota is regarded as the second set of the human genome and
plays an important role in human metabolism, immunity, and the occurrence and …

Stratification and prognostic evaluation of breast cancer subtypes defined by obesity-associated genes

D Chen, Z Xie, J Yang, T Zhang, Q Xiong, C Yi… - Discover Oncology, 2024 - Springer
Objective Breast cancer was the most common type of cancer among women worldwide,
significantly impacting their quality of life and survival rates. And obesity has been widely …

Exploring the Evolving Significance of lncRNA TUG1-mediated Signaling Pathways in Breast Cancer

M Abouali Gale Dari, A Anbiyaiee… - Current Signal …, 2024 - ingentaconnect.com
Breast cancer is one of the most common malignancies in women worldwide. Invasive
ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the most common kinds of …

Licochalcone A from licorice reprograms metabolic and antioxidant pathways in the breast leading to a tumor preventive environment.

A Hajirahimkhan, ET Bartom, S Chandrasekaran… - bioRxiv, 2024 - biorxiv.org
Several anti-estrogen drugs are proven to reduce breast cancer risk, but have had minimal
acceptance and impact, due to their side effects. Additionally, these do not reduce the risk of …