[HTML][HTML] Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks

RJ Perry, GI Shulman - Journal of Biological Chemistry, 2020 - ASBMB
In a healthy person, the kidney filters nearly 200 g of glucose per day, almost all of which is
reabsorbed. The primary transporter responsible for renal glucose reabsorption is sodium …

Systematic review of the impact of HbA1c on outcomes following surgery in patients with diabetes mellitus

KE Rollins, KK Varadhan, K Dhatariya, DN Lobo - Clinical nutrition, 2016 - Elsevier
Background & aims Diabetes is a significant risk factor for surgical complications and also
increases the prevalence of comorbidities, thereby increasing surgical risk. The aim of this …

Effect of A1C and glucose on postoperative mortality in noncardiac and cardiac surgeries

W van den Boom, RA Schroeder, MW Manning… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Hemoglobin A1c (A1C) is used in assessment of patients for elective surgeries
because hyperglycemia increases risk of adverse events. However, the interplay of A1C …

Association between type 2 diabetes and all-cause hospitalization and mortality in the UK general heart failure population: stratification by diabetic glycemic control …

CA Lawson, PW Jones, L Teece, SB Dunbar… - JACC: Heart Failure, 2018 - jacc.org
Objectives: This study sought to investigate in the general heart failure (HF) population,
whether the associations between type 2 diabetes (T2D) and risk of hospitalization and …

[HTML][HTML] Impact of preoperative glycometabolic status on outcomes in cardiac surgery: Systematic review and meta-analysis

C Corazzari, M Matteucci, M Kołodziejczak… - The Journal of Thoracic …, 2022 - Elsevier
Background Historically, impaired glucose metabolism has been associated with early and
late complicated clinical outcomes after cardiac surgery; however, such a condition is not …

[HTML][HTML] Low HbA1c and increased mortality risk-is frailty a confounding factor?

AH Abdelhafiz, AJ Sinclair - Aging and disease, 2015 - ncbi.nlm.nih.gov
Diabetes mellitus is increasingly becoming an older person disease due to the increased
survival and aging of the population. Previous studies which showed benefits of tight …

The effect of frailty should be considered in the management plan of older people with Type 2 diabetes

AH Abdelhafiz, L Koay, AJ Sinclair - Future science OA, 2016 - Taylor & Francis
The prevalence of diabetes is increasing especially in older age due to increased life
expectancy. In old age, diabetes is associated with high comorbidity burden and increased …

Hemoglobin A1c and Cardiovascular Outcomes Following Percutaneous Coronary Intervention: Insights From a Large Single-Center Registry

U Baber, L Azzalini, R Masoomi, G Johal… - Cardiovascular …, 2021 - jacc.org
Objectives The aim of this study was to evaluate post–percutaneous coronary intervention
(PCI) outcomes in relation to pre-procedural glycated hemoglobin (HbA1c) levels from a …

The association of glycated hemoglobin A1c with coronary artery disease, myocardial infarction, and severity of coronary lesions

Y Wei, W Li, H Luan, G Tuerhongjiang… - Journal of …, 2023 - journals.sagepub.com
Glycated hemoglobin A1c (HbA1c) has been recognized as a predictor of cardiovascular
events. However, the relationship between HbA1c and coronary artery disease (CAD) in the …

[HTML][HTML] Improving the accuracy of revised cardiac risk index with HbA1C: Hemoglobin ratio (HH ratio)–A retrospective cohort study

Y Ke, NB Shannon, HR Abdullah - Frontiers in Medicine, 2023 - frontiersin.org
Background The current Lee's Revised cardiac risk index (RCRI) was created in 1999.
Validation studies have found RCRI to be only moderately discriminant. The “Diabetes …