Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and …

A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT2AR) agonist,
may be associated with antidepressant effects. The mechanism behind its antidepressive …

Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals.
Here we report kinetic modeling and test–retest reproducibility assessment of the SV2A …

Transcription factors play vital roles in neuron development; however, little is known about
the role of these proteins in maintaining neuronal homeostasis. Here, we show that the …

In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

PET technology has produced many radiopharmaceuticals that target specific brain proteins
and other measures of brain function. Recently, a new approach has emerged to image …

More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …

Members of the synaptic vesicle glycoprotein 2 (SV2) family of proteins are involved in
synaptic function throughout the brain. The ubiquitously expressed SV2A has been widely …

Status epilepticus (SE) is a major clinical emergency that is associated with high mortality
and morbidity. SE causes significant neuronal injury and survivors are at a greater risk of …