Molecular mechanisms regulating NETosis in infection and disease

N Branzk, V Papayannopoulos - Seminars in immunopathology, 2013 - Springer
Neutrophils are the foot soldiers of the immune system. They home in to the site of infection
and kill pathogens by phagocytosis, degranulation, and the release of web-like structures …

Placental apoptosis in health and disease

AN Sharp, AEP Heazell, IP Crocker… - American journal of …, 2010 - Wiley Online Library
Citation Sharp AN, Heazell AEP, Crocker IP, Mor G. Placental apoptosis in health and
disease. Am J Reprod Immunol 2010; 64: 159–169 Apoptosis, programmed cell death, is an …

Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones

M Saffarzadeh, C Juenemann, MA Queisser, G Lochnit… - PloS one, 2012 - journals.plos.org
Neutrophils play an important role in innate immunity by defending the host organism
against invading microorganisms. Antimicrobial activity of neutrophils is mediated by release …

Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility

C Sur Chowdhury, S Giaglis, UA Walker… - Arthritis research & …, 2014 - Springer
Abstract Introduction Neutrophil extracellular traps (NETs) have recently been implicated in
a number of autoimmune conditions, including rheumatoid arthritis (RA). We examined the …

Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition

RS Keshari, A Jyoti, M Dubey, N Kothari, M Kohli… - PloS one, 2012 - journals.plos.org
Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic
inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been …

Prognostic utility and characterization of cell-free DNA in patients with severe sepsis

DJ Dwivedi, LJ Toltl, LL Swystun, J Pogue, KL Liaw… - Critical care, 2012 - Springer
Introduction Although sepsis is the leading cause of death in noncoronary critically ill
patients, identification of patients at high risk of death remains a challenge. In this study, we …

DAMP and DIC: the role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

PC Liaw, T Ito, T Iba, J Thachil, S Zeerleder - Blood reviews, 2016 - Elsevier
Disseminated intravascular coagulation (DIC) is a heterogeneous group of disorders, which
manifest as a spectrum of haemorrhage and thrombosis complicating many primary …

Role of neutrophil extracellular traps in health and disease pathophysiology: recent insights and advances

MM Islam, N Takeyama - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are the principal trouper of the innate immune system. Activated neutrophils
undergo a noble cell death termed NETosis and release a mesh-like structure called …

[HTML][HTML] The pathophysiological role of neutrophil extracellular traps in inflammatory diseases

A Bonaventura, L Liberale, F Carbone… - Thrombosis and …, 2018 - thieme-connect.com
Neutrophil pathogen-killing mechanism termed neutrophil extracellular traps (NETs) has
been recently identified. NETs consist of chromatin and histones along with serine proteases …

[HTML][HTML] Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis

D Awasthi, S Nagarkoti, S Sadaf, T Chandra… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Neutrophil extracellular traps (NETs) play a pivotal role in the innate immune defense, as
well as in the pathophysiology of various inflammatory disease conditions. Two major types …