Neuronal SNAREs and their key regulators together drive synaptic vesicle exocytosis and
synaptic transmission as a single integrated membrane fusion machine. Human pathogenic …

Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by
the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family …

Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs
are constitutively active, so a major focus has been to identify fusion clamps that regulate …

The revolution in genetic technology has ushered in a new age for our understanding of the
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …

Synaptic loss is the best correlate of cognitive deficits in Alzheimer's disease (AD). Extensive
experimental evidence also indicates alterations of synaptic properties at the early stages of …

Previously we reported that Synaptotagmin-1 and Complexin synergistically clamp the
SNARE assembly process to generate and maintain a pool of docked vesicles that fuse …

The brain extracellular matrix (ECM) consists of extremely long-lived proteins that assemble
around neurons and synapses, to stabilize them. The ECM is thought to change only rarely …

Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires
mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion …

The molecules and mechanisms behind chemical synaptic transmission have been
explored for decades. For several of the core proteins involved in synaptic vesicle fusion, we …

Neurotransmitter release is mediated by proteins that drive synaptic vesicle fusion with the
presynaptic plasma membrane. While soluble N-ethylmaleimide sensitive factor attachment …