Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

IL-17 is an important cytokine in the physiopathology of rheumatoid arthritis (RA). However,
its participation in the genesis of nociception during RA remains undetermined. In this study …

Transient receptor potential vanilloid 1 (TRPV1) channel is a tetrameric protein that acts as a
sensor for noxious stimuli such as heat and for diverse inflammatory mediators such as …

Background and purpose: Neutrophil migration into tissues is involved in the genesis of
inflammatory pain. Here, we addressed the hypothesis that the effect of CXC chemokines on …

ABSTRACT Peroxynitrite (ONOO−), the reaction product of the interaction between
superoxide (O2·−) and nitric oxide (· NO), is a potent proinflammatory and cytotoxic …

We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced
arthritis (ZYA) or collagen-induced arthritis (CIA). Rats and mice, respectively, received 1 mg …

The role of superoxide and its active byproduct peroxynitrite as mediators of nociceptive
signaling is emerging. We have recently reported that nitration and inactivation of spinal …

Seaweed lectins have been widely investigated as anti-nociceptive and anti-inflammatory
agents. This study analyzed the anti-nociceptive and anti-inflammatory responses of a lectin …