The therapeutic potential of carnosine as an antidote against drug-induced cardiotoxicity and neurotoxicity: Focus on nrf2 pathway

G Caruso, A Privitera, BM Antunes, G Lazzarino… - Molecules, 2022 - mdpi.com
Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-
fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral drugs, antipsychotic, and …

Selenoproteins in health

Z Qi, A Duan, K Ng - Molecules, 2023 - mdpi.com
Selenium (Se) is a naturally occurring essential micronutrient that is required for human
health. The existing form of Se includes inorganic and organic. In contrast to the inorganic …

Unveiling the hidden therapeutic potential of carnosine, a molecule with a multimodal mechanism of action: A position paper

G Caruso - Molecules, 2022 - mdpi.com
Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-
the-counter food supplement with a well-demonstrated multimodal mechanism of action that …

Oxidative and nitrosative stress in major depressive disorder: a case control study

A Somani, AK Singh, B Gupta, S Nagarkoti, PK Dalal… - Brain Sciences, 2022 - mdpi.com
Introduction: The role of increased oxidative stress and alterations to the nitric oxide (NO)
pathway have been implicated in major depressive disorder (MDD). The two pathways …

Nitrous oxide abuse: clinical outcomes, pharmacology, pharmacokinetics, toxicity and impact on metabolism

E Gernez, GR Lee, JP Niguet, F Zerimech, A Bennis… - Toxics, 2023 - mdpi.com
The recreational use of nitrous oxide (N2O), also called laughing gas, has increased
significantly in recent years. In 2022, the European Monitoring Centre for Drugs and Drug …

The therapeutic potential of novel carnosine formulations: perspectives for drug development

A Bonaccorso, A Privitera, M Grasso, S Salamone… - Pharmaceuticals, 2023 - mdpi.com
Carnosine (beta-alanyl-L-histidine) is an endogenous dipeptide synthesized via the activity
of the ATP-dependent enzyme carnosine synthetase 1 and can be found at a very high …

Anxiety and Alzheimer's disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

NC Reyna, BJ Clark, DA Hamilton… - Frontiers in Aging …, 2023 - frontiersin.org
Dementia remains one of the leading causes of morbidity and mortality in older adults.
Alzheimer's disease (AD) is the most common type of dementia, affecting over 55 million …

Chaperone-dependent mechanisms as a pharmacological target for neuroprotection

MV Voronin, EV Abramova, ER Verbovaya… - International Journal of …, 2023 - mdpi.com
Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic
and does not allow vicious circles causing disease development to break. Protein misfolding …

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

NA Alhakamy, G Caruso, A Privitera, OAA Ahmed… - Pharmaceutics, 2022 - mdpi.com
Impaired diabetic wound healing is a major concern for health care professionals worldwide,
imposing an intense financial burden and reducing the quality of life of patients. A …

Association between antidepressants and dementia risk in older adults with depression: a systematic review and meta-analysis

GHM Wang, P Li, Y Wang, J Guo, DL Wilson… - Journal of Clinical …, 2023 - mdpi.com
Depression, commonly treated with antidepressants, is associated with an increased risk of
dementia, especially in older adults. However, the association between antidepressant use …