Translational genomics and recent advances in oral squamous cell carcinoma

AWY Chai, KP Lim, SC Cheong - Seminars in cancer biology, 2020 - Elsevier
Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from
the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle …

Oral cavity carcinoma: current management, controversies, and future directions

SB Chinn, JN Myers - Journal of clinical oncology, 2015 - ascopubs.org
Oral cavity carcinoma (OCC) remains a major cause of morbidity and mortality in patients
with head and neck cancer. Although the incidence has decreased over the last decade …

TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response

G Zhou, Z Liu, JN Myers - Journal of cellular biochemistry, 2016 - Wiley Online Library
Recent studies describing the mutational landscape of head and neck squamous cell
carcinoma (HNSCC) on a genomic scale by our group and others, including The Cancer …

The molecular landscape of recurrent and metastatic head and neck cancers: insights from a precision oncology sequencing platform

LGT Morris, R Chandramohan, L West, A Zehir… - JAMA …, 2017 - jamanetwork.com
Importance Recurrent and/or metastatic head and neck cancer is usually incurable.
Implementation of precision oncology for these patients has been limited by incomplete …

Rising incidence of oral tongue cancer among white men and women in the United States, 1973–2012

JE Tota, WF Anderson, C Coffey, J Califano, W Cozen… - Oral oncology, 2017 - Elsevier
Background Despite significant reductions in tobacco use in the US, oral tongue cancer
incidence has reportedly increased in recent years, particularly in young white women. We …

Epidemiology and molecular biology of head and neck cancer

A Jou, J Hess - Oncology research and treatment, 2017 - karger.com
Head and neck cancer is a common and aggressive malignancy with a high morbidity and
mortality profile. Although the large majority of cases resemble head and neck squamous …

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

M Tagliabue, P Belloni, R De Berardinis… - Cancer …, 2021 - Wiley Online Library
While evidence suggests an increasing incidence of tongue cancer in young adults,
published findings regarding the prognostic role of age at diagnosis are inconsistent. We …

[HTML][HTML] Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)

C Michikawa, V Gopalakrishnan, AM Harrandah… - Neoplasia, 2022 - Elsevier
Recently, increased number of studies have demonstrated a relationship between the oral
microbiome and development of head and neck cancer, however, there are few studies to …

The mutational landscape of early‐and typical‐onset oral tongue squamous cell carcinoma

BR Campbell, Z Chen, DL Faden, N Agrawal, RJ Li… - Cancer, 2021 - Wiley Online Library
Background The incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing
among younger birth cohorts. The etiology of early‐onset OTSCC (diagnosed before the age …

Genetic characteristics of advanced oral tongue squamous cell carcinoma in young patients

S Kim, C Lee, H Kim, SO Yoon - Oral Oncology, 2023 - Elsevier
Objectives We aimed to investigate genetic alterations in oral tongue squamous cell
carcinoma (OTSCC) based on age and the clinical significance of these alterations in young …