Regulatory T cells in autoimmune disease
M Dominguez-Villar, DA Hafler - Nature immunology, 2018 - nature.com
In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …
considerably. Key observations have challenged the traditional definition of Treg cells and …
[HTML][HTML] ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
DY Li, XZ Xiong - Frontiers in immunology, 2020 - frontiersin.org
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …
Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression
Rationale: Regression of atherosclerosis is an important clinical goal; however, the
pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques …
pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques …
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
SJ Yang, AK Singh, T Drow, T Tappen… - Science Translational …, 2022 - science.org
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
[HTML][HTML] Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study
EM Shevach - Frontiers in immunology, 2018 - frontiersin.org
T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …
topic of intense investigation by immunologists. The initial doubts about their existence were …
[HTML][HTML] Reciprocal expression of IL-35 and IL-10 defines two distinct effector Treg subsets that are required for maintenance of immune tolerance
X Wei, J Zhang, Q Gu, M Huang, W Zhang, J Guo… - Cell reports, 2017 - cell.com
Regulatory T cells (Tregs) can exert their functions through multiple suppressive
mechanisms; however, it is unclear how Tregs exactly employ these mechanisms. In this …
mechanisms; however, it is unclear how Tregs exactly employ these mechanisms. In this …
[HTML][HTML] Regulatory T cell stability and plasticity in atherosclerosis
AJ Ali, J Makings, K Ley - Cells, 2020 - mdpi.com
Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …
Regulatory T‐cell stability and functional plasticity in health and disease
V Malviya, L Yshii, S Junius, AD Garg… - … and Cell Biology, 2023 - Wiley Online Library
FOXP3‐expressing regulatory T cells (Treg) are indispensable for immune homeostasis and
tolerance, and in addition tissue‐resident Treg have been found to perform noncanonical …
tolerance, and in addition tissue‐resident Treg have been found to perform noncanonical …
[HTML][HTML] The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis
Q Gu, X Zhao, J Guo, Q Jin, T Wang, W Xu, L Li… - Cell Reports, 2023 - cell.com
Foxp3 is the master transcription factor for regulatory T cells (Tregs). Alternative splicing of
human Foxp3 results in the expression of two isoforms: the full length and an exon 2-deleted …
human Foxp3 results in the expression of two isoforms: the full length and an exon 2-deleted …
[HTML][HTML] Peptide-based targeting of immunosuppressive cells in cancer
NT Trac, EJ Chung - Bioactive materials, 2020 - Elsevier
Cancer progression is marked by the infiltration of immunosuppressive cells, such as tumor-
associated macrophages (TAMs), regulatory T lymphocytes (Tregs), and myeloid-derived …
associated macrophages (TAMs), regulatory T lymphocytes (Tregs), and myeloid-derived …