[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Exercise benefits on Alzheimer's disease: State-of-the-science

PL Valenzuela, A Castillo-García, JS Morales… - Ageing research …, 2020 - Elsevier
Although there is no unanimity, growing evidence supports the value of regular physical
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …

Cognitive aging and the promise of physical activity

KI Erickson, SD Donofry, KR Sewell… - Annual Review of …, 2022 - annualreviews.org
Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …

Imaging the evolution and pathophysiology of Alzheimer disease

W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Resistance vs resilience to Alzheimer disease: clarifying terminology for preclinical studies

EM Arenaza-Urquijo, P Vemuri - Neurology, 2018 - AAN Enterprises
Preventing or delaying Alzheimer disease (AD) through lifestyle interventions will come from
a better understanding of the mechanistic underpinnings of (1) why a significant proportion …

[HTML][HTML] Cognitive reserve and the prevention of dementia: the role of physical and cognitive activities

ST Cheng - Current psychiatry reports, 2016 - Springer
Abstract Purpose of Review The article discusses the two most significant modifiable risk
factors for dementia, namely, physical inactivity and lack of stimulating cognitive activity, and …

HIITing the brain with exercise: mechanisms, consequences and practical recommendations

TA Calverley, S Ogoh, CJ Marley… - The Journal of …, 2020 - Wiley Online Library
The increasing number of older adults has seen a corresponding growth in those affected by
neurovascular diseases, including stroke and dementia. Since cures are currently …

Can physical exercise in old age improve memory and hippocampal function?

E Duzel, H van Praag, M Sendtner - Brain, 2016 - academic.oup.com
Physical exercise can convey a protective effect against cognitive decline in ageing and
Alzheimer's disease. While the long-term health-promoting and protective effects of exercise …

[PDF][PDF] Physical exercise in the oldest old.

PL Valenzuela, A Castillo-Garcia, JS Morales… - Age, 2019 - academia.edu
Societies are progressively aging, with the oldest old (ie., those aged> 80–85 years) being
the most rapidly expanding population segment. However, advanced aging comes at a …

Causes and patterns of dementia: an update in the era of redefining Alzheimer's disease

BD James, DA Bennett - Annual review of public health, 2019 - annualreviews.org
The burden of dementia continues to increase as the population ages, with no disease-
modifying treatments available. However, dementia risk appears to be decreasing, and …