Modulating glycolysis to improve cancer therapy
Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …
dominant'metabolic profile to promote their survival and meet their requirements for energy …
Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy
R Yue, C Zhang, L Xu, Y Wang, G Guan, L Lei, X Zhang… - Chem, 2022 - cell.com
Ferroptosis is of great significance for disease treatment and drug design because of its
effective damage to drug-resistant cells. However, ferroptosis-based therapy presents …
effective damage to drug-resistant cells. However, ferroptosis-based therapy presents …
Pushing adenosine and ATP SELEX for DNA aptamers with nanomolar affinity
The classical DNA aptamer for adenosine and ATP has been the most used small molecule
binding aptamer for biosensing, imaging, and DNA nanotechnology. This sequence has …
binding aptamer for biosensing, imaging, and DNA nanotechnology. This sequence has …
Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light
Z Su, D Xi, Y Chen, R Wang, X Zeng, T Xiong, X Xia… - Small, 2023 - Wiley Online Library
The combination of photodynamic therapy (PDT) and chemotherapy (chemo‐photodynamic
therapy) for enhancing cancer therapeutic efficiency has attracted tremendous attention in …
therapy) for enhancing cancer therapeutic efficiency has attracted tremendous attention in …
Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres
Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma
(GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor …
(GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor …
Targeting mitochondrial metabolism for metastatic cancer therapy
A Passaniti, MS Kim, BM Polster… - Molecular …, 2022 - Wiley Online Library
Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine
triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells …
triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells …
TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer
Abstract Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer
subtype suffering from limited targeted treatment options. Following recent reports …
subtype suffering from limited targeted treatment options. Following recent reports …
Recent insights into the effects of metabolism on breast cancer cell dormancy
S Bartlome, CC Berry - British Journal of Cancer, 2022 - nature.com
Breast cancer (BC) remains the most common cancer, as well as the leading cause of
cancer mortality in women worldwide. Approximately 30% of patients with early-stage BC …
cancer mortality in women worldwide. Approximately 30% of patients with early-stage BC …
DNA Aptamer beacon probe (ABP) for monitoring of adenosine triphosphate level in SW480 cancer cells treated with glycolysis inhibitor 2-deoxyglucose
K Ratajczak, M Stobiecka - International Journal of Molecular Sciences, 2023 - mdpi.com
Early cancer screening enables timely detection of carcinogenesis, and aids in prompt
clinical intervention. Herein, we report on the development of a simple, sensitive, and rapid …
clinical intervention. Herein, we report on the development of a simple, sensitive, and rapid …