Modulating glycolysis to improve cancer therapy

C Chelakkot, VS Chelakkot, Y Shin, K Song - International Journal of …, 2023 - mdpi.com
Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer

C Rocca, T Soda, EM De Francesco, M Fiorillo… - Journal of Translational …, 2023 - Springer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

R Yue, C Zhang, L Xu, Y Wang, G Guan, L Lei, X Zhang… - Chem, 2022 - cell.com
Ferroptosis is of great significance for disease treatment and drug design because of its
effective damage to drug-resistant cells. However, ferroptosis-based therapy presents …

Pushing adenosine and ATP SELEX for DNA aptamers with nanomolar affinity

Y Ding, J Liu - Journal of the American Chemical Society, 2023 - ACS Publications
The classical DNA aptamer for adenosine and ATP has been the most used small molecule
binding aptamer for biosensing, imaging, and DNA nanotechnology. This sequence has …

Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light

Z Su, D Xi, Y Chen, R Wang, X Zeng, T Xiong, X Xia… - Small, 2023 - Wiley Online Library
The combination of photodynamic therapy (PDT) and chemotherapy (chemo‐photodynamic
therapy) for enhancing cancer therapeutic efficiency has attracted tremendous attention in …

Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres

JK Shim, S Choi, SJ Yoon, RJ Choi, J Park… - Cancer Cell …, 2022 - Springer
Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma
(GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor …

Targeting mitochondrial metabolism for metastatic cancer therapy

A Passaniti, MS Kim, BM Polster… - Molecular …, 2022 - Wiley Online Library
Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine
triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells …

TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer

N Sim, JM Carter, K Deka, BKT Tan, Y Sim… - Nature …, 2024 - nature.com
Abstract Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer
subtype suffering from limited targeted treatment options. Following recent reports …

Recent insights into the effects of metabolism on breast cancer cell dormancy

S Bartlome, CC Berry - British Journal of Cancer, 2022 - nature.com
Breast cancer (BC) remains the most common cancer, as well as the leading cause of
cancer mortality in women worldwide. Approximately 30% of patients with early-stage BC …

DNA Aptamer beacon probe (ABP) for monitoring of adenosine triphosphate level in SW480 cancer cells treated with glycolysis inhibitor 2-deoxyglucose

K Ratajczak, M Stobiecka - International Journal of Molecular Sciences, 2023 - mdpi.com
Early cancer screening enables timely detection of carcinogenesis, and aids in prompt
clinical intervention. Herein, we report on the development of a simple, sensitive, and rapid …