Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs
N Di Caprio, JA Burdick - Acta biomaterialia, 2023 - Elsevier
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …
biological questions and as building blocks for engineered tissues. Spheroids possess …
Biomanufacturing human tissues via organ building blocks
The construction of human organs on demand remains a tantalizing vision to solve the
organ donor shortage. Yet, engineering tissues that recapitulate the cellular and …
organ donor shortage. Yet, engineering tissues that recapitulate the cellular and …
[HTML][HTML] Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing
Modular biofabrication strategies using microtissues or organoids as biological building
blocks have great potential for engineering replacement tissues and organs at scale. Here …
blocks have great potential for engineering replacement tissues and organs at scale. Here …
Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues
YM Efremov, IM Zurina, VS Presniakova… - Biophysical …, 2021 - Springer
Cell aggregates, including sheets and spheroids, represent a simple yet powerful model
system to study both biochemical and biophysical intercellular interactions. However, it is …
system to study both biochemical and biophysical intercellular interactions. However, it is …
Directed regeneration of osteochondral tissue by hierarchical assembly of spatially organized composite spheroids
The use of engineered scaffolds or stem cells is investigated widely in the repair of injured
musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral …
musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral …
Organotypic 3D decellularized matrix tumor spheroids for high-throughput drug screening
Decellularized extracellular matrix (dECM) is emerging as a valuable tool for generating 3D
in vitro tumor models that better recapitulate tumor-stroma interactions. However, the …
in vitro tumor models that better recapitulate tumor-stroma interactions. However, the …
Building a tissue: mesenchymal and epithelial cell spheroids mechanical properties at micro-and nanoscale
NV Kosheleva, YM Efremov, PI Koteneva, IV Ilina… - Acta Biomaterialia, 2023 - Elsevier
Cell transitions between the epithelial and mesenchymal phenotypes provide the regulated
morphogenesis and regeneration throughout the ontogenesis. The tissue mechanics and …
morphogenesis and regeneration throughout the ontogenesis. The tissue mechanics and …
Aspiration-assisted freeform bioprinting of mesenchymal stem cell spheroids within alginate microgels
Aspiration-assisted freeform bioprinting (AAfB) has emerged as a promising technique for
precise placement of tissue spheroids in three-dimensional (3D) space enabling tissue …
precise placement of tissue spheroids in three-dimensional (3D) space enabling tissue …
Spatially arranged encapsulation of stem cell spheroids within hydrogels for the regulation of spheroid fusion and cell migration
Mesenchymal stem cell spheroids have been encapsulated in hydrogels for various
applications because spheroids demonstrate higher cell activity than individual cells in …
applications because spheroids demonstrate higher cell activity than individual cells in …
Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages
H Isla-Magrané, A Veiga, J García-Arumí… - Stem cell research & …, 2021 - Springer
Background Recently, great efforts have been made to design protocols for obtaining ocular
cells from human stem cells to model diseases or for regenerative purposes. Current …
cells from human stem cells to model diseases or for regenerative purposes. Current …