Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

Mitochondria, the organelles classically seen as the powerhouse of the cell, are increasingly
associated with a wide variety of neurodevelopmental disorders. Although individually rare …

Background and Hypothesis The robust evidence base supporting the therapeutic benefit of
ketogenic diets in epilepsy and other neurological conditions suggests this same metabolic …

Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in
experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate …

Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy
associated with poor neurodevelopmental outcomes. When first-line treatment options …

Dietary restriction of carbohydrate has been demonstrated to be beneficial for nervous
system dysfunction in animal models and may be beneficial for human chronic pain. The …

Bioactive substances (BAS), such as small molecule drugs, proteins, RNA, cells, etc., play a
vital role in many therapeutic applications, especially in tissue repair and regeneration …

Previously, we showed that restrictive diets, including ketogenic diet (KD), have an anti-
inflammatory impact on the healthy gastrointestinal tract of mice. Afterward, we found that …

Emerging science continues to establish the detrimental effects of malnutrition in acute
neurological diseases such as traumatic brain injury, stroke, status epilepticus and anoxic …