Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum
anticancer drug family. These compounds induce apoptosis in tumor cells by binding to …

US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …

Abstract p53's apoptotic program consists of transcription-dependent and transcription-
independent pathways. In the latter, physical interactions between mitochondrial p53 and …

Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA
damage and inhibition of transcription. We report that a DNA minor groove binding hairpin …

Background TP53 is the most commonly mutated gene across all cancer types. R175H
mutation was considered structural mutation where the mutation causes misfolding of the …

General transcription is required for the growth and survival of all living cells. However,
tumor cells require extraordinary levels of transcription, including the transcription of …

Ageing is due to the accumulation of damage, which arises because of evolved limitations in
mechanisms for maintenance and repair. Accumulated damage may cause genomic …

Purpose: Cell cycle dysregulation resulting in expression of antiapoptotic genes and
uncontrolled proliferation is a feature of undifferentiated nasopharyngeal carcinoma. The …

It has been declared repeatedly that cancer is a result of molecular genetic abnormalities.
However, there has been no working model describing the specific functional consequences …

The RNA polymerase II transcription machinery acts as a molecular motor that traverses
large parts of the genome on a regular basis. It has been suggested that the transcription …