Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

The last decades have witnessed an exponential increase in our knowledge of Rho GTPase
signaling network which further highlighted the cross talk between these proteins and the …

Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

In collaboration or competition with many other actin-binding proteins, the actin-
depolymerizing factor/cofilins integrate transmembrane signals to coordinate the spatial and …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Dynamic plasma membrane rearrangements occur during many cellular processes
including endocytosis, morphogenesis, and migration. Actin polymerization together with …

The actin cytoskeleton powers membrane deformation during many cellular processes, such
as migration, morphogenesis, and endocytosis. Membrane phosphoinositides, especially …