Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
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Acetylcholine acts as a neurotransmitter in the central and peripheral nervous systems in
humans. However, recent experiments demonstrate a widespread expression of the …

Having identified renin in cardiac mast cells, we assessed whether its release leads to
cardiac dysfunction. In Langendorff-perfused guinea pig hearts, mast cell degranulation with …

The nonapeptide oxytocin is released into systemic circulation in situations of psychosocial
interaction, and has been shown to be involved in mechanisms of social bonding and social …

A diverse array of chemical agents have been self administered by humans to alter the
psychological state. Such drugs of abuse include both stimulants and depressants of the …

Our understanding of the cellular and molecular bases of transduction of painful stimuli has
burgeoned in the past year, mainly as a result of studies on isolated sensory neurones in …

BACKGROUND & AIMS: Lubiprostone alleviates constipation by stimulating intestinal fluid
secretion, purportedly through activation of ClC-2–type Cl− channels. Intestinal obstruction …

Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that
are ubiquitous, naturally occurring molecules. They form a recently identified class of …

The administration of the 5-hydroxytryptamine (5-HT) precursor 5hydroxytryptophan (5-
HTP)(25mg/kg IP), in combination with an inhibitor of peripheral 5-HTP decarboxylase …

Mice deficient in monoamine oxidase A (MAO A) have elevated brain levels of 5-HT and
manifest enhanced aggression. We used these mice as a model to study the role of 5-HT in …