In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …

Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …

Sclerostin is most recognized for its role in controlling bone formation but is also expressed
in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on …

Background The correlation of low serum albumin with mortality in patients with chronic
kidney disease (CKD) is partly linked to its association with systemic inflammation. However …

Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires
carboxylation by vitamin K to exert calcification inhibition. Chronic kidney disease (CKD) …

Background The value of subjective global assessment (SGA) as nutritional assessor of
protein-energy wasting (PEWSGA) in chronic kidney disease (CKD) patients depends on its …

Vascular calcification in chronic kidney disease is a very complex process traditionally
explained in multifactorial terms. Here we sought to clarify relevance of the diverse agents …

Osteoporosis characterized by low bone mineral density (BMD) as assessed by dual-energy
X-ray absorptiometry (DXA) is common among end-stage renal disease (ESRD) patients …

Advanced chronic kidney disease (CKD) is characterized by a premature aging phenotype
of multifactorial origin. Mitochondrial dysfunction is prevalent in CKD and has been …

Background Vascular calcification (VC) and renal osteodystrophy are important
complications of advanced chronic kidney disease (CKD). High resolution peripheral …