Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Background Marine prokaryotes are a rich source of novel bioactive secondary metabolites
for drug discovery. Recent genome mining studies have revealed their great potential to bio …

Natural products (NPs) have historically played a primary role in the discovery of small-
molecule drugs. However, due to the advent of other methodologies and the drawbacks of …

Oceans cover seventy percent of the planet's surface and besides being an immense
reservoir of biological life, they serve as vital sources for human sustenance, tourism …

Angucyclines are type II polyketide natural products, often characterized by unusual
structural rearrangements through B-or C-ring cleavage of their tetracyclic backbone. While …

The widespread emergence of antibiotic-resistant pathogens poses a severe threat to public
health. This problem becomes even worse with a coincident decline in the supply of new …

Horizontal gene transfer in bacteria is widely believed to occur via conjugation, transduction
and transformation. These mechanisms facilitate the passage of DNA across the protective …

Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown
that the vast majority of their biosynthetic potential has yet to be explored. However, many of …

Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast
majority has not yet been discovered, among others because the hidden chemical space is …