Excessive activation of microglia and subsequent release of proinflammatory cytokines play
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …

Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

Background Inflammatory response mediated by oxidative stress is considered as an
important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products …

Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

Postoperative cognitive dysfunction (POCD) is a common postoperative complication
involving the central nervous system, but the underlying mechanism is not well understood …

Hsp60 is a chaperone belonging to the Chaperonins of Group I and typically functions inside
mitochondria in which, together with the co-chaperonin Hsp10, maintains protein …

The heat-shock response, one of the main pro-survival mechanisms of a living organism,
has evolved as the biochemical response of cells to cope with heat stress. The most well …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

Background Spinal cord injury (SCI) is a devastating disease that lacks effective treatment.
Interestingly, recent studies indicated that vagus nerve stimulation (VNS), neuromodulation …

Physiological changes in animals exposed to elevated ambient temperature are
characterized by the redistribution of blood toward the periphery to dissipate heat, with a …