One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

Abstract S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during
many acute and chronic inflammatory disorders. However, the precise mechanism of its …

How disseminated tumour cells engage specific stromal components in distant organs for
survival and outgrowth is a critical but poorly understood step of the metastatic cascade …

The microenvironment, or niche, surrounding a stem cell largely governs its cellular fate.
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone …

Inherited disease susceptibility in humans is most commonly associated with single
nucleotide polymorphisms (SNPs). The mechanisms by which this occurs are still poorly …

RNAs localizing to the outer cell surface have been recently identified in mammalian cells,
including RNAs with glycan modifications known as glycoRNAs. However, the functional …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

1Angiogenesis is a fundamental process in reproduction and wound healing. Under these
conditions, neovascularization is tightly regulated. Unregulated angiogenesis may lead to …

The selectin family of adhesion molecules mediates the initial attachment of leukocytes to
venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury …