Mitochondrial DNA copy number variation across human cancers
Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are
observed throughout cancers. Here, we survey mtDNA copy number variation across 22 …
observed throughout cancers. Here, we survey mtDNA copy number variation across 22 …
Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity
F Villarroya, P Domingo, M Giralt - Trends in pharmacological sciences, 2005 - cell.com
The lipodystrophy syndrome and associated metabolic alterations are the most prevalent
adverse effects in HIV-infected patients taking highly active anti-retroviral therapy (HAART) …
adverse effects in HIV-infected patients taking highly active anti-retroviral therapy (HAART) …
HIV and mitochondrial toxicity in children
C Foster, H Lyall - Journal of Antimicrobial Chemotherapy, 2008 - academic.oup.com
In the last 10 years, the enormous impact of combination antiretroviral (ARV) therapy on
paediatric HIV-associated mortality and morbidity in well-resourced settings and its role in …
paediatric HIV-associated mortality and morbidity in well-resourced settings and its role in …
Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia
The objective of the present study was to determine the mitochondrial toxicity mechanisms of
linezolid-related hyperlactatemia. Five patients on a long-term schedule of linezolid …
linezolid-related hyperlactatemia. Five patients on a long-term schedule of linezolid …
Mitochondrial damage in adipose tissue of untreated HIV-infected patients
Objective: Antiretrovirals, especially thymidine-analogue nucleoside reverse transcriptase
inhibitors (tNRTIs), may cause the mitochondrial damage in adipose tissue that has been …
inhibitors (tNRTIs), may cause the mitochondrial damage in adipose tissue that has been …
In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells
F Vidal, JC Domingo, J Guallar, M Saumoy… - Antimicrobial agents …, 2006 - Am Soc Microbiol
We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those of zidovudine
(AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in …
(AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in …
Impact of mitochondrial toxicity of HIV-1 antiretroviral drugs on lipodystrophy and metabolic dysregulation
F Eoin R, M Patrick WG - Current pharmaceutical design, 2010 - ingentaconnect.com
Nucleoside reverse transcriptase inhibitors (NRTIs) are components of most current
antiretroviral (ARV) regimens. Side effects arising from mitochondrial toxicity (MtT) induced …
antiretroviral (ARV) regimens. Side effects arising from mitochondrial toxicity (MtT) induced …
Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients
H Shao, D Lan, Z Duan, Z Liu, J Min, L Zhang… - Journal of Clinical …, 2006 - Springer
The observations that Lymphopenia is common in severe acute respiratory syndrome
(SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by …
(SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by …
Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?
A Maagaard, D Kvale - Journal of Antimicrobial Chemotherapy, 2009 - academic.oup.com
Mitochondrial toxicity contributes to serious adverse effects observed in HIV-infected
individuals treated with nucleoside reverse transcriptase inhibitors (NRTIs). However, similar …
individuals treated with nucleoside reverse transcriptase inhibitors (NRTIs). However, similar …
Possible ways nucleoside analogues can affect mitochondrial DNA content and gene expression during HIV therapy
HCF Côté - Antiviral Therapy, 2005 - journals.sagepub.com
In recent years, research into nucleoside reverse transcriptase inhibitor (NRTI)-related
mitochondrial (mt) toxicity in HIV therapy has led to conflicting results and many unanswered …
mitochondrial (mt) toxicity in HIV therapy has led to conflicting results and many unanswered …