Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are
observed throughout cancers. Here, we survey mtDNA copy number variation across 22 …

The lipodystrophy syndrome and associated metabolic alterations are the most prevalent
adverse effects in HIV-infected patients taking highly active anti-retroviral therapy (HAART) …

In the last 10 years, the enormous impact of combination antiretroviral (ARV) therapy on
paediatric HIV-associated mortality and morbidity in well-resourced settings and its role in …

The objective of the present study was to determine the mitochondrial toxicity mechanisms of
linezolid-related hyperlactatemia. Five patients on a long-term schedule of linezolid …

Objective: Antiretrovirals, especially thymidine-analogue nucleoside reverse transcriptase
inhibitors (tNRTIs), may cause the mitochondrial damage in adipose tissue that has been …

We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those of zidovudine
(AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in …

Nucleoside reverse transcriptase inhibitors (NRTIs) are components of most current
antiretroviral (ARV) regimens. Side effects arising from mitochondrial toxicity (MtT) induced …

The observations that Lymphopenia is common in severe acute respiratory syndrome
(SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by …

Mitochondrial toxicity contributes to serious adverse effects observed in HIV-infected
individuals treated with nucleoside reverse transcriptase inhibitors (NRTIs). However, similar …

In recent years, research into nucleoside reverse transcriptase inhibitor (NRTI)-related
mitochondrial (mt) toxicity in HIV therapy has led to conflicting results and many unanswered …