Human organoids: tools for understanding biology and treating diseases
F Schutgens, H Clevers - Annual Review of Pathology …, 2020 - annualreviews.org
Organoids are in vitro–cultured three-dimensional structures that recapitulate key aspects of
in vivo organs. They can be established from pluripotent stem cells and from adult stem …
in vivo organs. They can be established from pluripotent stem cells and from adult stem …
Early‐onset colorectal cancer in young individuals
Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need,
especially as diagnosis in this population might lead to the greatest loss of years of life …
especially as diagnosis in this population might lead to the greatest loss of years of life …
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Mutational processes underlie cancer initiation and progression. Signatures of these
processes in cancer genomes may explain cancer etiology and could hold diagnostic and …
processes in cancer genomes may explain cancer etiology and could hold diagnostic and …
Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
DNA damage and associated DNA repair defects in disease and premature aging
Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
Childhood cancer predisposition syndromes—a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric …
T Ripperger, SS Bielack, A Borkhardt… - American journal of …, 2017 - Wiley Online Library
Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …
Although a large number of cancer predisposition genes and their associated syndromes …
Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
N Stjepanovic, L Moreira, F Carneiro… - Annals of …, 2019 - annalsofoncology.org
Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with
identification of new genes. Similarly, a better understanding of the genotype/phenotype …
identification of new genes. Similarly, a better understanding of the genotype/phenotype …
Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis
Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …
Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine
This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …
cancer (CRC), with an overview of gene variant classification. We include updates on the …