The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

The brain and behavior are under energetic constraints, limited by mitochondrial energy
transformation capacity. However, the mitochondria-behavior relationship has not been …

Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including
Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …

Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but
underlying mechanisms are not understood. Analyses of 700 human blood transcriptomes …

Sickle cell disease (SCD) is an inherited blood disorder characterized by sickled red blood
cells (RBCs), which are more sensitive to haemolysis and can contribute to disease …