Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …

Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively
balanced male to female sex ratio is generally expected. However, selection may shift the …

Engineered sex ratio distorters (SRDs) have been proposed as a powerful component of
genetic control strategies designed to suppress harmful insect pests. Two types of CRISPR …

CRISPR-based genetic engineering tools aimed to bias sex ratios, or drive effector genes
into animal populations, often integrate the transgenes into autosomal chromosomes …

In vertebrates, enzymes responsible for DNA methylation, one of the epigenetic
mechanisms, are encoded by genes falling into the cytosine methyltransferases genes …

Genetic control strategies aimed to bias the sex of progenies towards males present a
promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio …

Understanding development and genetic regulation in the Anopheles gambiae germline is
essential to engineer effective genetic control strategies targeting this malaria mosquito …

Sex-ratio distorters based on X-chromosome shredding are more efficient than sterile male
releases for population suppression. X-shredding is a form of sex distortion that skews …

Genes that originate during evolution are an important source of novel biological functions.
Retrogenes are functional copies of genes produced by retroduplication and as such are …