Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

S Mirzaei, MH Gholami, A Zabolian, H Saleki… - Pharmacological …, 2021 - Elsevier
As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …

Tailored functionalization of natural phenols to improve biological activity

B Floris, P Galloni, V Conte, F Sabuzi - Biomolecules, 2021 - mdpi.com
Phenols are widespread in nature, being the major components of several plants and
essential oils. Natural phenols' anti-microbial, anti-bacterial, anti-oxidant, pharmacological …

Competent synthesis of biaryl analogs via asymmetric Suzuki–Miyaura cross-coupling for the development of anti-inflammatory and analgesic agents

HD Gurupadaswamy, VL Ranganatha, R Ramu… - Journal of the Iranian …, 2022 - Springer
Based on the core structure of diflunisal drug, herein, we report a resembling series of biaryl
analogs (3a–j) containing halogens, nitro, and methoxy substituents. They were designed …

Synthesis, crystal structure, DFT calculations, Hirshfeld surface analysis, energy frameworks, molecular dynamics and docking studies of novel isoxazolequinoxaline …

N Abad, HH Sallam, FH Al-Ostoot, HA Khamees… - Journal of Molecular …, 2021 - Elsevier
Quinoxaline derivatives with the molecular formula [C 8 H 6 N 2] also named
benzopyrazines, which are a valuable class of heterocyclic compounds useful for their …

Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

OM Alshehri, A Zeb, SM Mukarram Shah… - Frontiers in …, 2024 - frontiersin.org
The strong ethnopharmacological utilization of Isodon rugosus Wall. Ex. Benth is evident in
the treatment of several types of pain and inflammation, including toothache, earache …

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

I Mssillou, A Agour, M Slighoua, M Chebaibi… - Pharmaceuticals, 2022 - mdpi.com
Burns constitute a major challenge in medical science, and plants can be part of the
solution. Dittrichia viscosa L.(Asteraceae) and Marrubium vulgare L.(Lamiaceae) are widely …

Structural and theoretical exploration of a multi-methoxy chalcone: Synthesis, quantum theory, electrostatics, molecular packing, DFT analysis, and in-silico anti …

FH Al-Ostoot, P Akhileshwari, VH Kameshwar… - Heliyon, 2024 - cell.com
This study explores the pharmacological potential of chalcones through a multidisciplinary
approach, including synthesis, quantum theory, molecular electrostatics, and density …

Multi-crosslinked network chitosan films containing caffeic acid and Fe3+ with high anti-oxidation and anti-UV abilities

K Xu, H Li, X Huang, Z Qin - International Journal of Biological …, 2022 - Elsevier
In this study, caffeic acid (CA) and Fe 3+ were added to chitosan solution to prepare
chitosan/caffeic acid/Fe 3+(CCAF) composite films. CA was used to introduce covalent …

Synthesis, characterization, DFT, docking studies and molecular dynamics of some 3-phenyl-5-furan isoxazole derivatives as anti-inflammatory and anti-ulcer agents

HM Pallavi, FH Al-Ostoot, HK Vivek… - Journal of Molecular …, 2022 - Elsevier
A vast number of nitrogen heterocyclic derivatives comprising oxygen atom is considered as
a valuable combination of therapeutic agents in curative chemistry. In particular, isoxazole, a …

Synthesis, crystal structure, Hirshfeld surface analysis, DFT calculations, 3D energy frameworks studies of Schiff base derivative 2, 2′-((1Z, 1′ Z)-(1, 2-phenylene bis …

KM Chandini, FH Al-Ostoot, EE Shehata… - Journal of Molecular …, 2021 - Elsevier
Abstract The title compound 2, 2′-((1Z, 1′ Z)-(1, 2-phenylene bis (azanylylidene)) bis
(methanylylidene)) diphenol was synthesized with a good yield. The crude product was …