The mechanisms leading to cellular damage from ischemia-reperfusion (I/R) injury are
complex and multi-factorial. Accumulating evidence suggests an important role for oxidative …

The central nervous system is lined by meninges, classically known as dura, arachnoid, and
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …

Introduction 3. Technical considerations 3.1. Cranial window 3.2. Intravital fluorescence
microscopy 3.3. Ischemia models 4. Inflammatory responses to I/R 4.1. Leukocyte adhesion …

Transgenic sickle mice expressing βS hemoglobin have activated vascular endothelium that
exhibits enhanced expression of NF-κB and adhesion molecules that promote vascular …

Background and Purpose—Leukocytes contribute to cerebral ischemia-reperfusion injury.
However, few experimental models examine both in vivo behavior of leukocytes and …

We assessed the acute effects of radiation on the rat blood–brain barrier. A cranial window
model and intravital microscopy were used to measure changes in permeability and …

Spontaneous and experimental metastasis can be effectively inhibited by the widely used
anticoagulant heparin in different tumor models. At the cellular level, many of the …

To examine the role of the platelet adhesion molecule von Willebrand factor (vWf) in
atherogenesis, vWf-deficient mice (vWf−/−) were bred with mice lacking the low-density …

The implantation of biomaterials into the human body has become an indispensable part of
almost all fields of modern medicine. Accordingly, there is an increasing need for …

Scaffolds for tissue engineering should be biocompatible and stimulate rapid blood vessel
ingrowth. Herein, we analyzed in vivo the biocompatibility and vascularization of three novel …