The Phenix software for automated determination of macromolecular structures
PD Adams, PV Afonine, G Bunkóczi, VB Chen… - Methods, 2011 - Elsevier
X-ray crystallography is a critical tool in the study of biological systems. It is able to provide
information that has been a prerequisite to understanding the fundamentals of life. It is also a …
information that has been a prerequisite to understanding the fundamentals of life. It is also a …
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in …
CD Putnam, M Hammel, GL Hura… - Quarterly reviews of …, 2007 - cambridge.org
Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …
analyses; however, it is restricted to describing low energy conformations of …
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
E Yankova, W Blackaby, M Albertella, J Rak… - Nature, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) is an abundant internal RNA modification, that is
catalysed predominantly by the METTL3–METTL14 methyltransferase complex,. The m6A …
catalysed predominantly by the METTL3–METTL14 methyltransferase complex,. The m6A …
Inhibition of METTL3 results in a cell-intrinsic interferon response that enhances antitumor immunity
AA Guirguis, Y Ofir-Rosenfeld, K Knezevic, W Blackaby… - Cancer Discovery, 2023 - AACR
Therapies that enhance antitumor immunity have altered the natural history of many
cancers. Consequently, leveraging nonoverlapping mechanisms to increase …
cancers. Consequently, leveraging nonoverlapping mechanisms to increase …
[PDF][PDF] CCP4i2: the new graphical user interface to the CCP4 program suite
L Potterton, J Agirre, C Ballard, K Cowtan… - … Section D: Structural …, 2018 - journals.iucr.org
The CCP4 (Collaborative Computational Project, Number 4) software suite for
macromolecular structure determination by X-ray crystallography groups brings together …
macromolecular structure determination by X-ray crystallography groups brings together …
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
Abstract γ-Amino acids can play important roles in the biological activities of natural
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme
C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are
generally considered to be chemically inert, the recent emergence of methods for C–H …
generally considered to be chemically inert, the recent emergence of methods for C–H …
Alkyne derivatives of SARS-CoV-2 main protease inhibitors including nirmatrelvir inhibit by reacting covalently with the Nucleophilic Cysteine
Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination
with ritonavir, is used to treat infections by severe acute respiratory syndrome coronavirus-2 …
with ritonavir, is used to treat infections by severe acute respiratory syndrome coronavirus-2 …
Computational design of self-assembling protein nanomaterials with atomic level accuracy
We describe a general computational method for designing proteins that self-assemble to a
desired symmetric architecture. Protein building blocks are docked together symmetrically to …
desired symmetric architecture. Protein building blocks are docked together symmetrically to …
[PDF][PDF] Overview of the CCP4 suite and current developments
The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of
programs and associated data and software libraries which can be used for macromolecular …
programs and associated data and software libraries which can be used for macromolecular …