It has been more than 50 years since antinuclear antibodies were first discovered and found
to be associated with connective tissue diseases. Since then different methods have been …

The methods for detecting and measuring autoantibodies have evolved markedly in recent
years, encompassing three generations of analytical technologies. Many different …

The following guideline presents a series of recommendations based on published medical
literature for use of the antinuclear antibody (ANA) test and tests for specific autoantibodies …

Abstract The Italian Society of Laboratory Medicine Study Group on the Diagnosis of
Autoimmune Diseases has generated a series of guidelines for the laboratory diagnosis and …

Objective To determine the performance characteristics of enzyme‐based immunoassay
(EIA) kits for the detection of antinuclear and other autoantibodies of defined specificities …

Objective. To compare the measurement of antinuclear antibodies (ANA) by
immunofluorescence and by 6 different commercial enzyme‐linked immunosorbent assays …

Introduction The indirect immunofluorescence assay on HEp-2 cells (HEp-2/IFA) is used
worldwide for screening for autoantibodies to cellular antigens. Cell culture and fixation …

Antibodies to extractable nuclear antigens (ENA) are found in a variety of collagen vascular
diseases. Determining the individual specificities of these antibodies is extremely useful in …

Detection of antinuclear antibodies (ANA) is a fundamental laboratory test for diagnosing
systemic autoimmune diseases. Currently, the method of choice is indirect …

Detection of antinuclear (ANA) and antineutrophil cytoplasmic (ANCA) antibodies is
extensively used for establishing a diagnosis in patients with clinical features suggestive of …