Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …

One target, one drug has been the dominant drug discovery paradigm in recent decades.
This paradigm is based on the concept that the symptoms or progression of a given disease …

Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …

Alzheimer's disease (AD), like other multifactorial diseases, is the result of a systemic
breakdown of different physiological networks. As result, several lines of evidence suggest …