Bacterial enhancer binding proteins (bEBPs) are transcriptional activators that assemble as
hexameric rings in their active forms and utilize ATP hydrolysis to remodel the conformation …

The initiation of transcription is a complex process involving many different steps. These
steps are all potential control points for regulating gene expression, and many have been …

Can the time, location, and magnitude of future earthquakes be predicted reliably and
accurately? In their Perspective, Geller et al.'s answer is “no.” Citing recent results from the …

The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional
endocytic receptor that is expressed abundantly in neurons of the CNS. Both LRP and …

Gene transcription is carried out by RNA polymerase (RNAP) and requires the conversion of
the initial closed promoter complex, where DNA is double stranded, to a transcription …

Cellular RNA polymerase is a multi-subunit macromolecular assembly responsible for gene
transcription, a highly regulated process conserved from bacteria to humans. In bacteria …

Bacterial sigma (σ) factors confer gene specificity upon the RNA polymerase, the central
enzyme that catalyses gene transcription. The binding of the alternative σ factor σ54 confers …

The replication‐initiator protein DnaA is ubiquitous in the eubacterial world. It binds to an
asymmetric 9 bp consensus DNA sequence, the DnaA box. Besides its primary function as …

Transcriptional enhancers are cis-acting DNA elements that are binding sites for regulatory
proteins and function at large distances from promoter elements to stimulate transcription …

Transcriptional activator proteins that act upon the σ54‐containing form of the bacterial RNA
polymerase belong to the extensive AAA+ superfamily of ATPases, members of which are …