Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …

INTRODUCTION Cancer is a leading cause of death worldwide, and there is great need to
define the molecular mechanisms driving the development and progression of individual …

Hepatoma cell lines are frequently used as in vitro alternatives to primary human
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …

The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely
characterized. We report that fatty acid synthase knockdown (FASN KD) in ECs impedes …

We have developed a new expression vector which allows efficient selection for
transfectants that express foreign genes at high levels. The vector is composed of a …

Analysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals
that 17 of the major human plasma proteins are synthesized and secreted by these cells …

HEPATOCELLULAR carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and
eastern Asia1. Hepatitis B virus and aflatoxins are risk factors for HCC2, but the molecular …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

Chemotherapeutic drugs cause DNA damage and kill cancer cells mainly by apoptosis. p53
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell …