Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …

Uterine smooth muscle tumor of uncertain malignant potential is a subtype of uterine smooth
muscle neoplasms. It is characterized by distinct pathologic findings with morphologic …

Uterine leiomyosarcomas (ULMSs) are aggressive smooth muscle tumors associated with
poor clinical outcome. Despite previous cytogenetic and molecular studies, their molecular …

Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an
infiltrative growth pattern and a high local recurrence rate. Here we report the genetic and …

Background Alternative lengthening of telomeres (ALT) is a telomerase-independent
mechanism used by a broad range of neoplasms to maintain telomere length, permitting …

The morphologic assessment of uterine leiomyosarcoma (LMS) may be challenging, and
diagnostic immunohistochemical (IHC) analysis is currently lacking. We evaluated the …

Although diagnosis of high-grade uterine mesenchymal tumors (UMTs) exhibiting classic
morphologic features is straightforward, diagnosis is more challenging in tumors in which …

Telomere maintenance mechanisms (ie, telomerase activity (TA) and the alternative
lengthening of telomere (ALT) mechanism) contribute to tumorigenesis by providing …

Simple Summary A clinical test for alternative-lengthening-of-telomeres (ALT) could assist
with cancer diagnosis and monitoring of disease progression. ALT-targeted anticancer …

Recurrent genomic mutations in uterine and non-uterine leiomyosarcomas have not been
well established. Using a next generation sequencing (NGS) panel of common cancer …