Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

More and more cancer studies use next-generation sequencing (NGS) data to detect various
types of genomic variation. However, even when researchers have such data at hand, single …

Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes. To better
understand neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome …

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most
common extracranial tumor of childhood. By sequencing transcriptomes of low-and high-risk …

Abstract Purpose of Review The evolving information of the initiation, tumor cell
heterogeneity, and plasticity of childhood neuroblastoma has opened up new perspectives …

Purpose Children diagnosed at age≥ 18 months with metastatic MYCN-nonamplified
neuroblastoma (NBL-NA) are at high risk for disease relapse, whereas those diagnosed at …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …

High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in
ALK. Currently, high-risk NB presents significant clinical challenges, and additional …