Carotid intima-media thickness progression as surrogate marker for cardiovascular risk: meta-analysis of 119 clinical trials involving 100 667 patients
Background: To quantify the association between effects of interventions on carotid intima-
media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk …
media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk …
Raising the bar for using surrogate endpoints in drug regulation and health technology assessment
Raising the bar for using surrogate endpoints in drug regulation and health technology
assessment Page 1 Raising the bar for using surrogate endpoints in drug regulation and health …
assessment Page 1 Raising the bar for using surrogate endpoints in drug regulation and health …
Estimation of productivity gain by irrigated and fertilized forage palm plants ('Opuntia ficus-indica'(L.) Mill. and Nopalea cochenillifera (L.) Salm-Dyck): systematic …
RL de Souza Ferraz, P da Silva Costa… - Australian Journal of …, 2019 - search.informit.org
Population expansion increases the water use for food production, which has stimulated
farmers to cultivate vegetable with improved water use efficiency. The purpose of this meta …
farmers to cultivate vegetable with improved water use efficiency. The purpose of this meta …
Evaluation of variation in the performance of GFR slope as a surrogate end point for kidney failure in clinical trials that differ by severity of CKD
Background The GFR slope has been evaluated as a surrogate end point for kidney failure
in meta-analyses on a broad collection of randomized controlled trials (RCTs) in CKD …
in meta-analyses on a broad collection of randomized controlled trials (RCTs) in CKD …
Bivariate network meta‐analysis for surrogate endpoint evaluation
Surrogate endpoints are very important in regulatory decision making in healthcare, in
particular if they can be measured early compared to the long‐term final clinical outcome …
particular if they can be measured early compared to the long‐term final clinical outcome …
[HTML][HTML] Predicting Treatment Effects from Surrogate Endpoints in Historical Trials in First-line Metastatic Castration-resistant Prostate Cancer
Background Surrogate endpoints are becoming increasingly important in health technology
assessment, where decisions are based on complex cost-effectiveness models (CEMs) that …
assessment, where decisions are based on complex cost-effectiveness models (CEMs) that …
Bayesian hierarchical meta‐analytic methods for modeling surrogate relationships that vary across treatment classes using aggregate data
Surrogate endpoints play an important role in drug development when they can be used to
measure treatment effect early compared to the final clinical outcome and to predict clinical …
measure treatment effect early compared to the final clinical outcome and to predict clinical …
Bayesian meta‐analytical methods to incorporate multiple surrogate endpoints in drug development process
A number of meta‐analytical methods have been proposed that aim to evaluate surrogate
endpoints. Bivariate meta‐analytical methods can be used to predict the treatment effect for …
endpoints. Bivariate meta‐analytical methods can be used to predict the treatment effect for …
Using bayesian evidence synthesis methods to incorporate real-world evidence in surrogate endpoint evaluation
L Wheaton, A Papanikos, A Thomas… - Medical Decision …, 2023 - journals.sagepub.com
Objective Traditionally, validation of surrogate endpoints has been carried out using
randomized controlled trial (RCT) data. However, RCT data may be too limited to validate …
randomized controlled trial (RCT) data. However, RCT data may be too limited to validate …
Multivariate meta-analysis
Multivariate meta-analysis may be appropriate when some or all studies in a meta-analysis
report more than one outcome. This chapter describes the multivariate meta-analysis model …
report more than one outcome. This chapter describes the multivariate meta-analysis model …