Detect accessible chromatin using ATAC-sequencing, from principle to applications
Y Sun, N Miao, T Sun - Hereditas, 2019 - Springer
Background Chromatin accessibility is crucial for gene expression regulation in specific cells
and in multiple biological processes. Assay for Transposase Accessible Chromatin with high …
and in multiple biological processes. Assay for Transposase Accessible Chromatin with high …
[HTML][HTML] Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease
Mechanical forces provide critical biological signals to cells during healthy and aberrant
organ development as well as during disease processes in adults. Within the …
organ development as well as during disease processes in adults. Within the …
Development and validation of asthma risk prediction models using co-expression gene modules and machine learning methods
Asthma is a heterogeneous respiratory disease characterized by airway inflammation and
obstruction. Despite recent advances, the genetic regulation of asthma pathogenesis is still …
obstruction. Despite recent advances, the genetic regulation of asthma pathogenesis is still …
In-silico identification and prioritization of therapeutic targets of asthma
I Mallick, P Panchal, S Kadam, P Mohite, J Scheele… - Scientific Reports, 2023 - nature.com
Asthma is a “common chronic disorder that affects the lungs causing variable and recurring
symptoms like repeated episodes of wheezing, breathlessness, chest tightness and …
symptoms like repeated episodes of wheezing, breathlessness, chest tightness and …
Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma
G Ijpma, L Kachmar, A Panariti… - European …, 2020 - Eur Respiratory Soc
Constriction of airways during asthmatic exacerbation is the result of airway smooth muscle
(ASM) contraction. Although it is generally accepted that ASM is hypercontractile in asthma …
(ASM) contraction. Although it is generally accepted that ASM is hypercontractile in asthma …
In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma
I Janulaityte, A Januskevicius… - International journal of …, 2020 - mdpi.com
Eosinophils infiltration and releasing TGF-β 1 in the airways has been implicated in the
pathogenesis of asthma, especially during acute episodes provoked by an allergen. TGF-β 1 …
pathogenesis of asthma, especially during acute episodes provoked by an allergen. TGF-β 1 …
Asthmatic eosinophils alter the gene expression of extracellular matrix proteins in airway smooth muscle cells and pulmonary fibroblasts
The impaired production of extracellular matrix (ECM) proteins by airway smooth muscle
cells (ASMC) and pulmonary fibroblasts (PF) is a part of airway remodeling in asthma. This …
cells (ASMC) and pulmonary fibroblasts (PF) is a part of airway remodeling in asthma. This …
[HTML][HTML] TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts
A Jin, X Tang, W Zhai, Y Li, Q Sun, L Liu, X Yang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Airway wall remodeling, a main pathology of asthma was linked to vitamin-D deficiency and
protein arginine methyltransferase-1 (PRMT1) expression in sub-epithelial cell layers …
protein arginine methyltransferase-1 (PRMT1) expression in sub-epithelial cell layers …
Unravelling the complexity of tissue inflammation in uncontrolled and severe asthma
JS Erjefält - Current Opinion in Pulmonary Medicine, 2019 - journals.lww.com
Asthma is vastly heterogeneous with multiple and superimposed inflammatory and
anatomical phenotypes. Despite the intensive research and introduction of highly immune …
anatomical phenotypes. Despite the intensive research and introduction of highly immune …
Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract in a murine model of steroid-insensitive …
Y Qian, Y Sun, Y Chen, Z Mao, Y Shi, D Wu… - Pharmaceutical …, 2022 - Taylor & Francis
Context Grape seed proanthocyanidin extract (GSPE) is effective in treating severe asthma
(SA). Objective To examine the relationship between Nrf2-miR-29b axis and SA, and to …
(SA). Objective To examine the relationship between Nrf2-miR-29b axis and SA, and to …