3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
[HTML][HTML] Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast
HE Mischo, NJ Proudfoot - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …
A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
Architecture of eukaryotic mRNA 3′-end processing machinery
Newly transcribed eukaryotic precursor messenger RNAs (pre-mRNAs) are processed at
their 3′ ends by the~ 1-megadalton multiprotein cleavage and polyadenylation factor …
their 3′ ends by the~ 1-megadalton multiprotein cleavage and polyadenylation factor …
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans
V Boreikaite, TS Elliott, JW Chin… - Genes & …, 2022 - genesdev.cshlp.org
Abstract 3′ end processing of most human mRNAs is carried out by the cleavage and
polyadenylation specificity factor (CPSF; CPF in yeast). Endonucleolytic cleavage of the …
polyadenylation specificity factor (CPSF; CPF in yeast). Endonucleolytic cleavage of the …
Birth of a poly (A) tail: mechanisms and control of mRNA polyadenylation
JB Rodríguez‐Molina, M Turtola - FEBS Open Bio, 2023 - Wiley Online Library
During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐
end processing reaction in which the pre‐mRNA is cleaved and released from the …
end processing reaction in which the pre‐mRNA is cleaved and released from the …
Activation of the endonuclease that defines mRNA 3′ ends requires incorporation into an 8-subunit core cleavage and polyadenylation factor complex
Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for
formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds …
formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds …
Delineating the structural blueprint of the pre-mRNA 3′-end processing machinery
Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
Reconstitution of mammalian cleavage factor II involved in 3′ processing of mRNA precursors
P Schäfer, C Tüting, L Schönemann, U Kühn, T Treiber… - Rna, 2018 - rnajournal.cshlp.org
Cleavage factor II (CF II) is a poorly characterized component of the multiprotein complex
catalyzing 3′ cleavage and polyadenylation of mammalian mRNA precursors. We have …
catalyzing 3′ cleavage and polyadenylation of mammalian mRNA precursors. We have …
Mpe1 senses the binding of pre-mRNA and controls 3′ end processing by CPF
JB Rodríguez-Molina, FJ O'Reilly, H Fagarasan… - Molecular Cell, 2022 - cell.com
Most eukaryotic messenger RNAs (mRNAs) are processed at their 3′ end by the cleavage
and polyadenylation specificity factor (CPF/CPSF). CPF mediates the endonucleolytic …
and polyadenylation specificity factor (CPF/CPSF). CPF mediates the endonucleolytic …