Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

Sheep pulmonary adenomatosis (SPA) is a contagious and experimentally transmissible
lung cancer of sheep resembling human bronchiolo-alveolar carcinoma. A type D retrovirus …

Enzymes are versatile and efficient biological catalysts that drive numerous cellular
processes, motivating the development of enzyme design approaches to tailor catalysts for …

To clarify how the location of distal histidine affects the activation process of H 2 O 2 by
heme proteins, we have characterized reactions with H 2 O 2 for the L29H/H64L and …

Mechanisms of sulfoxidation catalyzed by high-valent intermediates of heme enzymes have
been investigated by direct observation of sulfide-induced reduction of three different …

The reaction between hydroperoxides and the haem group of proteins and enzymes is
important for the function of many enzymes but has also been implicated in a number of …

A series of myoglobin mutants, in which distal sites are modified by site-directed
mutagenesis, are able to catalyze peroxidase, catalase, and P450 reactions even though …

Random mutagenesis and screening for enzymatic activity has been used to engineer horse
heart myoglobin to enhance its intrinsic peroxidase activity. A chemically synthesized gene …

We have studied the competitive epoxidations of olefins with cis-and trans-stilbenes and
with cyclooctene and trans-stilbene in iron porphyrin complex-catalyzed epoxidation …