Rhenium-188 (188Re) is a high energy beta-emitting radioisotope with a short 16.9 h
physical half-life, which has been shown to be a very attractive candidate for use in …

The monoclonal antibody (mAb) revolution that currently provides many new options for the
treatment of neoplastic and inflammatory diseases has largely bypassed the field of …

No significant improvement in therapy of pancreatic cancer has been reported over the last
25 y, underscoring the urgent need for new alternative therapies. Here, we coupled a …

PURPOSE: Protection of bone marrow against radiotoxicity during radioimmunotherapy and
in some cases external beam radiation therapy such as hemi-body irradiation would permit …

The use of indwelling medical devices (eg pacemakers, prosthetic joints, catheters, etc)
continues to increase, yet these devices are all too often complicated by infections with …

Background Wangiella dermatitidis is a human pathogenic fungus that is an etiologic agent
of phaeohyphomycosis. W. dermatitidis produces a black pigment that has been identified …

Asparagine deamidation is a decisive event in chemotherapy-induced apoptosis and a
major obstacle in the formulation of monoclonal antibodies. Despite the importance of …

Simple Summary Metastatic melanoma is a deadly disease that claims thousands of lives
each year despite the introduction of several new drugs into the clinic over the past decade …

Melanocortin-1 receptor (MC1-R) and melanin are two attractive melanoma-specific targets
for peptide-targeted radionuclide therapy for melanoma. Radiolabeled peptides targeting …

Background The HIV epidemic is a major threat to health in the developing and western
worlds. A modality that targets and kills HIV-1-infected cells could have a major impact on …