Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Abstract Background and Aims The inflammatory bowel diseases [IBD], Crohn's disease and
ulcerative colitis, are chronic, idiopathic gastrointestinal diseases. Although their precise …

Mammalian brain glycome remains a relatively poorly understood area compared to other
large-scale “omics” studies, such as genomics and transcriptomics due to the inherent …

Formalin-fixed and paraffin-embedded (FFPE) tissue specimens are the gold standard for
histological examination, and they provide valuable molecular information in tissue-based …

The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …

Significance: Alzheimer disease (AD) is an all-too-common condition in the aging
population. However, aging does not automatically equal neurodegeneration and memory …

Altered energy metabolism has been implicated both in aging and the pathogenesis of late-
onset Alzheimer's disease (LOAD). However, it is unclear which anomalies are acquired …

Age-related neurological disorders (ANDs), including neurodegenerative diseases, are
multifactorial disorders with a risk that increases with aging. ANDs are generally …