Treatment of relapsed acute myeloid leukemia

F Thol, A Ganser - Current treatment options in oncology, 2020 - Springer
Opinion statement Relapse is still a common scenario in acute myeloid leukemia (AML)
treatment and occurs in 40–50% of younger and the great majority of elderly patients. The …

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

H Döhner, E Estey, D Grimwade… - Blood, The Journal …, 2017 - ashpublications.org
The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and
management of acute myeloid leukemia (AML) in adults, published in 2010, has found …

Venetoclax combined with azacitidine and homoharringtonine in relapsed/refractory AML: a multicenter, phase 2 trial

H Jin, Y Zhang, S Yu, X Du, N Xu, R Shao, D Lin… - Journal of Hematology & …, 2023 - Springer
Background Relapsed or refractory acute myeloid leukemia (R/R AML) has a dismal
prognosis. The aim of this study was to investigate the activity and tolerability of venetoclax …

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

NR Mathew, F Baumgartner, L Braun, D O'Sullivan… - Nature medicine, 2018 - nature.com
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …

CD38-directed CAR-T cell therapy: a novel immunotherapy strategy for relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

Q Cui, C Qian, N Xu, L Kang, H Dai, W Cui… - Journal of Hematology & …, 2021 - Springer
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative
treatment for acute myeloid leukemia (AML). However, most patients experience relapse …

Relapse of AML after hematopoietic stem cell transplantation: methods of monitoring and preventive strategies. A review from the ALWP of the EBMT

P Tsirigotis, M Byrne, C Schmid, F Baron… - Bone marrow …, 2016 - nature.com
Allogeneic hematopoietic stem cell transplantation (allo-SCT) remains the therapeutic
method with the most potent anti-leukemic activity mediated by the graft versus leukemia …

[HTML][HTML] CC-486 maintenance after stem cell transplantation in patients with acute myeloid leukemia or myelodysplastic syndromes

M De Lima, B Oran, RE Champlin… - Biology of Blood and …, 2018 - Elsevier
Relapse is the main cause of treatment failure after allogeneic stem cell transplant (alloSCT)
in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Injectable …

Relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia: an overview of prevention and treatment

F Kreidieh, I Abou Dalle, N Moukalled… - International Journal of …, 2022 - Springer
Despite therapeutic progress in acute myeloid leukemia (AML), relapse post-allogeneic
hematopoietic stem cell transplantation (allo-HSCT) remains a major challenge. Here, we …

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: prevention, detection, and treatment

C Rautenberg, U Germing, R Haas, G Kobbe… - International journal of …, 2019 - mdpi.com
Acute myeloid leukemia (AML) is a phenotypically and prognostically heterogeneous
hematopoietic stem cell disease that may be cured in eligible patients with intensive …

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

FM Uhl, S Chen, D O'Sullivan… - Science translational …, 2020 - science.org
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation
(allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after …