The effective regeneration of weight‐bearing bone defects and critical‐sized cartilage
defects remains a significant clinical challenge. Traditional treatments such as autologous …

Abstract Globally, more than 1.5 million patients undergo bone graft surgeries annually, and
the development of biomaterial scaffolds that mimic natural bone for bone grafting remains a …

Bone formation is a complex regeneration process that was regulated by many signalling
pathways, such as Wnt, Notch, BMP and Hedgehog (Hh). All of these signalling have been …

More than 20 million individuals worldwide suffer from congenital or acquired bone defects
annually. The development of bone scaffold materials that simulate natural bone for bone …

Osteoblasts, cells derived from mesenchymal stem cells (MSCs) in the bone marrow, are
cells responsible for bone formation and remodeling. The differentiation of osteoblasts from …

Osteoarthritis (OA) is a common multifactorial degenerative articular disease among the
aging population. The current investigation aimed to elucidate the function of microRNA-495 …

Objective Chondrogenesis and endochondral ossification in mandibular condyle play
crucial roles in maxillofacial morphogenesis and function. Circadian regulator brain and …

The hedgehog (Hh) signaling pathway is an evolutionarily conserved pathway that regulates
embryonic development in vertebrates. However, strong evidence suggests the role of its …

The large incidence of bone defects in clinical practice increases not only the demand for
advanced bone transplantation techniques but also the development of bone substitute …

ABSTRACT microRNA (miRNA) mediated regulation represents a highly efficient
posttranscriptional mechanism for controlling intracellular protein expression. In the past …