Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

G Cox, GD Wright - International Journal of Medical Microbiology, 2013 - Elsevier
The intrinsic antibiotic resistome is a naturally occurring phenomenon that predates
antibiotic chemotherapy and is present in all bacterial species. In addition to the intrinsic …

[HTML][HTML] A synthetic antibiotic class overcoming bacterial multidrug resistance

MJ Mitcheltree, A Pisipati, EA Syroegin, KJ Silvestre… - Nature, 2021 - nature.com
The dearth of new medicines effective against antibiotic-resistant bacteria presents a
growing global public health concern. For more than five decades, the search for new …

Acinetobacter baumannii: Emergence of a Successful Pathogen

AY Peleg, H Seifert, DL Paterson - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Acinetobacter baumannii has emerged as a highly troublesome pathogen for many
institutions globally. As a consequence of its immense ability to acquire or upregulate …

[HTML][HTML] Multidrug resistant acinetobacter

V Manchanda, S Sanchaita… - Journal of global infectious …, 2010 - journals.lww.com
Emergence and spread of Acinetobacter species, resistant to most of the available
antimicrobial agents, is an area of great concern. It is now being frequently associated with …

Structure− activity relationships of polymyxin antibiotics

T Velkov, PE Thompson, RL Nation… - Journal of medicinal …, 2010 - ACS Publications
The world is facing an enormous and growing threat from the emergence of bacteria that are
resistant to almost all available antibiotics. 1 Multidrug resistance is a significant public …

Acinetobacter baumannii: Epidemiology, Antimicrobial Resistance, and Treatment Options

GM Eliopoulos, LL Maragakis… - Clinical infectious …, 2008 - academic.oup.com
Multidrug-resistant Acinetobacter baumannii is recognized to be among the most difficult
antimicrobial-resistant gram-negative bacilli to control and treat. Increasing antimicrobial …

Global Challenge of Multidrug-Resistant Acinetobacter baumannii

F Perez, AM Hujer, KM Hujer, BK Decker… - Antimicrobial agents …, 2007 - Am Soc Microbiol
We may soon be facing the end of the “antibiotic era.” The initial and seemingly unstoppable
success of antibiotics, the fruit of human ingenuity, has been countered by an escalation of …

Acinetobacter infection

LS Munoz-Price, RA Weinstein - New England Journal of …, 2008 - Mass Medical Soc
The gram-negative coccobacillus acinetobacter, a pathogen once seen only in hot, humid
climates, has become an increasingly common nosocomial problem even in temperate …

[PDF][PDF] Antibacterial mechanisms of polymyxin and bacterial resistance

Z Yu, W Qin, J Lin, S Fang, J Qiu - Biomed Res Int, 2015 - downloads.hindawi.com
Multidrug resistance in pathogens is an increasingly significant threat for human health.
Indeed, some strains are resistant to almost all currently available antibiotics, leaving very …